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A novel synonymous mutation of SARS-COV-2: Is this possible to affect their antigenicity and immunogenicity?
Vaccines Số 2, năm 2020 (Tập 8, trang -)
ISSN: 2076393X
ISSN: 2076393X
DOI: 10.3390/vaccines8020220
Tài liệu thuộc danh mục: Scopus
Article
English
Từ khóa: epitope; amino acid substitution; antigenicity; Article; coronavirus disease 2019; gene; gene mutation; gene sequence; human; immune system; immunogenicity; phylogeny; S gene; SARS coronavirus; serology; Severe acute respiratory syndrome coronavirus 2; synonymous mutation
Tóm tắt tiếng anh
The S glycoprotein of coronaviruses is important for viral entry and pathogenesis with most variable sequences. Therefore, we analyzed the S gene sequences of SARS-CoV-2 to better understand the antigenicity and immunogenicity of this virus in this study. In phylogenetic analysis, two subtypes (SARS-CoV-2a and-b) were confirmed within SARS-CoV-2 strains. These two subtypes were divided by a novel synonymous mutation of D614G. This may play a crucial role in the evolution of SARS-CoV-2 to evade the host immune system. The region containing this mutation point was confirmed as a B-cell epitope located in the S1 domain, and SARS-CoV-2b strains exhibited severe reduced antigenic indexes compared to SARS-CoV-2a in this area. This may allow these two subtypes to have different antigenicity. If the two subtypes have different serological characteristics, a vaccine for both subtypes will be more effective to prevent COVID-19. Thus, further study is urgently required to confirm the antigenicity of these two subtypes. � 2020 by the authors. Licensee MDPI, Basel, Switzerland.
