• Chỉ mục bởi
  • Năm xuất bản
LIÊN KẾT WEBSITE

Amorphous silica nanoparticles derived from biowaste via microwave combustion for drug delivery

Araichimani s, Jai Shree Venkatesha College of Arts and Science, Dharmapuri, Tamil Nadu, India|
Mikhail V. (37101555200) | Evgeny (57057275500); Gorshenkov | N. (57194008700); Kolesnikov Department of Physical Materials Science, National University of Science and Technology “MISiS”, Moscow, Russian Federation| Gopalu (55480032500); Van Minh Department of Functional Nanosystems and High-Temperature Materials, National University of Science and Technology “MISiS”, Moscow, Russian Federation| K.M. (57210762299); Karunakaran Institute of Research and Development, Duy Tan University, Danang, Viet Nam| G. (55430366400); Prabu Department of Fine Chemistry, Biosensor Research Institute, Seoul National University of Science and Technology (Seoul Tech), Seoul, South Korea| P. (57216442043); Suresh Kumar Department of Physics, K.S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode, Tamil Nadu, India|

International Journal of Applied Ceramic Technology Số 3, năm 2021 (Tập 18, trang 583-589)

ISSN: 1546542X

ISSN: 1546542X

DOI: 10.1111/ijac.13693

Tài liệu thuộc danh mục:

Article

English

Từ khóa: Antibiotics; Biocompatibility; Combustion; Escherichia coli; Nanoparticles; Silica; Silica nanoparticles; Surface chemistry; Targeted drug delivery; Amorphous silica; Bacterial infections; Bacterial inhibition; Controlled delivery; Drug delivery vehicles; Microwave-assisted combustions; Release kinetics; Susceptibility tests; Controlled drug delivery
Tóm tắt tiếng anh
Amorphous silica nanoparticles are a promising platform for constructing drug delivery vehicles owing to their high biocompatibility and favorable surface chemistry. In the current study, we report the preparation of amorphous silica nanoparticles using rice husk biowaste via easy and rapid microwave-assisted combustion. The obtained results from various characterizations indicate that the prepared sample is an amorphous form of silica nanoparticles having sizes 50–80 nm with high purity. Ciprofloxacin was used as the model drug and it was released from silica nanocarrier in a controlled and prolonged manner. The ciprofloxacin release kinetics was investigated using the Higuchi model and Ritger-Peppas model which corroborate that different process like desorption, diffusion, and surface erosion may be involved in the release of ciprofloxacin from the prepared silica nanocarrier. The antibacterial susceptibility test revealed that the ciprofloxacin loaded silica nanocarrier exhibit a bacterial inhibition zone about 32 ± 4 and 44 ± 3 mm against Escherichia coli and Staphylococcus aureus, respectively. This study can be useful to develop a versatile nanocarrier with controlled delivery of ciprofloxacin to treat different types of bacterial infections. © 2020 The American Ceramic Society

Xem chi tiết