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Comparison of comorbidities in relation to critical conditions among coronavirus disease 2019 patients: A network meta-analysis
Infection and Chemotherapy Số , năm 2021 (Tập 53, trang -)
ISSN: 20932340
ISSN: 20932340
DOI: 10.3947/IC.2020.0136
Tài liệu thuộc danh mục:
Article
English
Từ khóa: adult; adult respiratory distress syndrome; Article; cardiovascular disease; chronic kidney failure; chronic liver disease; chronic obstructive lung disease; comorbidity; comparative study; controlled study; coronavirus disease 2019; diabetes mellitus; female; heart injury; human; hypertension; kidney disease; liver disease; liver injury; major clinical study; male; medical ethics; meta analysis; systematic review
Tóm tắt tiếng anh
development of critical conditions in coronavirus disease 2019 (COVID-19) patients. Pooled estimates of relative risks (RRs) and their 95% confidence intervals (CIs) were calculated by conducting a meta-analysis and network meta-analysis of 18 studies. Chronic obstructive pulmonary disease (COPD) was most strongly associated with the overall critical condition (RR = 4.22, 95% CI = 3.12 – 5.69), followed by cardiovascular disease (CVD) (RR = 3.00, 95% CI = 2.41 – 3.73), malignancy (RR = 2.91, 95% CI = 2.16 – 3.91), cerebrovascular accident (CVA) (RR = 2.86, 95% CI = 1.95 – 4.19), diabetes (RR = 2.10, 95% CI = 2.16 – 3.91), hypertension (RR = 2.02, 95% CI = 1.82 – 2.23), and chronic kidney disease (RR = 2.00, 95% CI = 1.36 – 2.94). The presence of comorbidities except for chronic liver disease and chronic kidney disease significantly increased the risk of severe infection, intensive care unit (ICU) admission, and cardiac injury in the subgroup analysis by types of critical conditions. Preexisting hypertension and diabetes additionally increased the risk of acute respiratory distress syndrome (ARDS). Among comorbidities, COPD had the highest probability of leading to severe COVID-19, ICU admission, and liver injury, while malignancy was most likely to cause ARDS and cardiac injury. In summary, preexisting COPD, CVD, CVA, hypertension, diabetes, and malignancy are more likely to worsen the progression of COVID-19, with severe infection, ICU admission requirement, and cardiac injury development. isi Provisional Copyright © 2021 by The Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, and The Korean Society for AIDS This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Pr
