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Effects of mucoadhesive polymers on released particles and drug release in solid lipid particle-based buccal tablets
Anti-Cancer Agents in Medicinal Chemistry Số 14, năm 2021 (Tập 21, trang 1894-1900)
ISSN: 18715206
ISSN: 18715206
DOI: 10.2174/1871520621666201207091827
Tài liệu thuộc danh mục:
Article
English
Từ khóa: Drug Compounding; Drug Delivery Systems; Drug Liberation; Lipids; Particle Size; Polymers; Prednisolone; Tablets; carbomer; ibuprofen; macrogol; nanocapsule; nanoparticle; polymer; polysorbate 80; prednisolone; solid lipid nanoparticle; lipid; polymer; alopecia; Article; buccal drug administration; controlled study; drug bioavailability; drug delivery system; drug dosage form; drug formulation; drug penetration; drug release; drug solubility; drug stability; emulsion; encapsulation; eye toxicity; freeze drying; high performance liquid chromatography; in vitro study; infrared spectroscopy; lipid body; matrix tablet; mean residence time; mucoadhesion; nicotine replacement therapy; nonhuman; particle size; scanning electron microscopy; sustained drug release; swelling; tablet disintegration; tablet hardness; tensile strength; ultrasound assisted extraction; X ray diffraction; zeta potential; chemistry; drug release; synthesis; tablet manufacture
Tóm tắt tiếng anh
Background: Mucoadhesive polymers play a critical role in controlled-release tablets for buccal drug delivery. Objective: This research aimed to investigate the characterization and mechanisms of solid lipid particle-based tablets with different mucoadhesive polymers for buccal delivery. Methods: Prednisolone (PSL)-loaded Solid Lipid Particles (SLPs) were conventionally prepared by ultrasonication. The freeze-drying method was used to convert the SLP suspension into a solid dosage form for buccal delivery by using mucoadhesive polymers. Results: All formulations showed over 80% drug release after 6h, which followed immediate and sustained release patterns depending on the SLP type. However, the different polymers in the formulations resulted in different mucoadhesion times and drug release and drug permeability profiles. HPMC 4000 showed higher drug permeation (3327 μg vs. 2589 μg after 6h) but a shorter mucoadhesion time than Carbopol (197 min vs. 361 min). In addition, surface morphology, swelling and erosion, particle size and zeta potential were also noted for the different mechanisms for buccal tablet design with different controlled release profiles. Conclusion: The results of this work indicate a good strategy for the selection of mucoadhesive polymers for SLP-based tablets in improving the bioavailability of poorly water-soluble drugs. © 2021 Bentham Science Publishers.
