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Genetic susceptibility of ace2 and tmprss2 in six common cancers and possible impacts on covid-19
Cancer Research and Treatment Số 3, năm 2021 (Tập 53, trang 650-656)
ISSN: 15982998
ISSN: 15982998
DOI: 10.20538/1682-0363-2021-2-71-78
Tài liệu thuộc danh mục:
Article
English
Từ khóa: Adenocarcinoma; Angiotensin-Converting Enzyme 2; Breast Neoplasms; Case-Control Studies; COVID-19; Databases as Topic; Female; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Humans; Liver Neoplasms; Lung Neoplasms; Male; Mutation; Neoplasms; Pandemics; Prognosis; Prostatic Neoplasms; Retrospective Studies; SARS-CoV-2; Serine Endopeptidases; Survival Analysis; angiotensin converting enzyme 2; transmembrane protease serine 2; ACE2 protein, human; serine proteinase; TMPRSS2 protein, human; adult; Article; breast carcinoma; cancer prognosis; cancer survival; cancer susceptibility; colon adenocarcinoma; controlled study; coronavirus disease 2019; disease free survival; female; gene expression profiling; gene expression regulation; gene function; gene overexpression; genetic susceptibility; human; liver cell carcinoma; lung adenocarcinoma; major clinical study; male; mortality risk; overall survival; pathway enrichment analysis; prostate adenocarcinoma; risk reduction; stomach adenocarcinoma; upregulation; adenocarcinoma; breast tumor; case control study; complication; data base; gastrointestinal tumor; genetic predisposition; genetics; liver tumor; lung tumor; mutation; neoplasm; pandemic; physiology; prognosis; prostate tumor; retrospective study; survival analysis; breast cancer; breast carcinoma; cancer localization; cancer mortality; cancer tissue; colon adenocarcinoma; colorectal cancer; genetic susceptibility; invasive carcinoma; liver cancer; liver cell carcinoma; lung adenocarcinoma; lung cancer; prostate adenocarcinoma; prostate cancer; protein expression; protein expression level; stomach adenocarcinoma; stomach cancer
Tóm tắt tiếng anh
Purpose Coronavirus disease 2019 (COVID-19) pandemic has spread worldwide rapidly and patients with cancer have been considered as a vulnerable group for this infection. This study aimed to examine the expressions of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) in tumor tissues of six common cancer types. Materials and Methods The expression levels of ACE2 and TMPRSS2 in tumors and control samples were obtained from online databases. Survival prognosis and biological functions of these genes were investigated for each tumor type. Results There was the overexpression of ACE2 in colon and stomach adenocarcinomas compared to controls, meanwhile colon and prostate adenocarcinomas showed a significantly higher expression of TMPRSS2. Additionally, survival prognosis analysis has demonstrated that upregulation of ACE2 in liver hepatocellular carcinoma was associated with higher overall survival (hazard ratio, 0.65; p=0.016) and disease-free survival (hazard ratio, 0.66; p=0.007), while overexpression of TMPRSS2 was associated with a 26% reduced risk of death in lung adenocarcinoma (p=0.047) but 50% increased risk of death in breast invasive carcinoma (p=0.015). Conclusion There is a need to take extra precautions for COVID-19 in patients with colorectal cancer, stomach cancer, and lung cancer. Further information on other types of cancer at different stages should be investigated. � 2021 Korean Cancer Association. All rights reserved.
