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Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

Raoult D. | Brouqui P. | Rolain J.-M. | La Scola B. | Colson P. | Tissot Dupont H. | Courjon J. Department of Virology, Biological and Pathological Center, Centre Hospitalier Universitaire de Nice, Nice, 06200, France| Hoang V.T. Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam| Parola P. Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France| Lagier J.-C. Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France|

International Journal of Antimicrobial Agents Số 1, năm 2020 (Tập 56, trang -)

DOI: 10.1016/j.ijantimicag.2020.105949

Tài liệu thuộc danh mục: ISI, Scopus

English

English

Từ khóa: azithromycin; hydroxychloroquine; azithromycin; hydroxychloroquine; adolescent; adult; age distribution; Article; child; clinical article; clinical effectiveness; clinical feature; clinical practice; clinical trial; concentration response; controlled study; coronavirus disease 2019; demography; female; human; infection control; lower respiratory tract infection; male; practice guideline; priority journal; sex difference; throat culture; treatment outcome; treatment response; upper respiratory tract infection; virus load; Betacoronavirus; combination drug therapy; Coronavirus infection; middle aged; pandemic; polymerase chain reaction; virus pneumonia; Adult; Azithromycin; Betacoronavirus; Coronavirus Infections; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Middle Aged; Pandemics; Pneumonia, Viral; Polymerase Chain Reaction; Viral Load
Tóm tắt tiếng anh
Background: Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the effect of hydroxychloroquine on respiratory viral loads. Patients and methods: French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16th, to receive 600mg of hydroxychloroquine daily and their viral load in nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical presentation, azithromycin was added to the treatment. Untreated patients from another center and cases refusing the protocol were included as negative controls. Presence and absence of virus at Day6-post inclusion was considered the end point. Results: Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms. Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration than reported in the litterature for untreated patients. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination. Conclusion: Despite its small sample size, our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin. � 2020

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