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Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards
European Journal of Clinical Microbiology and Infectious Diseases Số 6, năm 2020 (Tập 39, trang 1059-1061)
DOI: 10.1007/s10096-020-03913-9
Tài liệu thuộc danh mục: ISI, Scopus
English
English
Từ khóa: azithromycin; hydroxychloroquine; virus RNA; virus RNA; animal cell; Article; coronavirus disease 2019; Ct value; drug efficacy; hospital discharge; human; infectious disease ward; major clinical study; microbiological parameters; nonhuman; priority journal; real time reverse transcription polymerase chain reaction; Severe acute respiratory syndrome coronavirus 2; Vero C1008 cell line; viral load testing; virus gene; virus isolation; ward; animal; Betacoronavirus; Chlorocebus aethiops; Coronavirus infection; France; hospital discharge; isolation and purification; pandemic; physiology; reverse transcription polymerase chain reaction; specimen handling; Vero cell line; virology; virus load; virus pneumonia; Animals; Betacoronavirus; Chlorocebus aethiops; Coronavirus Infections; France; Humans; Pandemics; Patient Discharge; Pneumonia, Viral; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Specimen Handling; Vero Cells; Viral Load
Tóm tắt tiếng anh
In a preliminary clinical study, we observed that the combination of hydroxychloroquine and azithromycin was effective against SARS-CoV-2 by shortening the duration of viral load in Covid-19 patients. It is of paramount importance to define when a treated patient can be considered as no longer contagious. Correlation between successful isolation of virus in cell culture and Ct value of quantitative RT-PCR targeting E gene suggests that patients with Ct above 33–34 using our RT-PCR system are not contagious and thus can be discharged from hospital care or strict confinement for non-hospitalized patients. © 2020, The Author(s).
