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Anti-cholinesterase activity of lycopodium alkaloids from vietnamese huperzia squarrosa (Forst.) Trevis
Molecules Số 11, năm 2014 (Tập 19, trang 19172-19179)
ISSN: 14203049
ISSN: 14203049
DOI: 10.3390/molecules191119172
Tài liệu thuộc danh mục: Scopus
Article
English
Từ khóa: alkaloid; cholinesterase inhibitor; huperzine A; huperzine B; huperzinine; plant extract; sesquiterpene; chemistry; Huperzia; IC50; Lycopodium; Alkaloids; Cholinesterase Inhibitors; Huperzia; Inhibitory Concentration 50; Lycopodium; Plant Extracts; Sesquiterpenes
Tóm tắt tiếng anh
A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8α-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa. Among them, lycosquarosine A (1) is the new metabolite of the natural source. Lycosquarosine A completely inhibited AChE activity in a dose dependent manner with an IC50 value of 54.3 μg/mL, while acetylaposerratinine (2) showed stronger inhibitory activity than 1 with an IC50 value of 15.2 μg/mL. This result indicates that these alkaloids may be a potent source of AChE inhibitors. © 2014 by the authors licensee MDPI Basel Switzerland.
