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Antidiabetic and Renoprotective Effects of Ethyl Acetate Fraction of Mimosa pudica Linn. Leaves Extract in Streptozotocin-Induced Diabetic Mice

Lan Deparment of Pharmacology and Clinical Pharmacy, University of Medicine and Pharmacy, Vietnam National University, Ha Noi, Viet Nam|
Bui Thanh (55979134800) | Pham Thi Nguyet (57222901823); Tung | Dao Thi (57212105968); Hang | Phan Hong (57348392800); Vui | Vu Thi (57212299449); Minh Hanoi University of Pharmacy, Ha Noi, Viet Nam| Tran Thi Huyen (57981876400); Thom National Institute of Medicinal Materials, Ha Noi, Viet Nam| Pham Thi (57262122500); Trang Faculty of Pharmacy, Hanoi University of Business and Technology, Ha Noi, Viet Nam|

Current Bioactive Compounds Số 10, năm 2022 (Tập 18, trang 9-18)

ISSN: 15734072

ISSN: 15734072

DOI: 10.2174/1573407218666220307103828

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Tóm tắt tiếng anh
induced diabetes type 2 by strepto-zotocin (STZ) at a low dose and treated with EtOAc fraction of M. pudica leaves at 50 mg/kg and 100 mg/kg b.w for 60 days. After 24 hours of the final dose of therapy, the mice were sacrificed to extract blood and kidney tissues for biochemical and histopathological analysis. Results: The EtOAc fraction of M. pudica leaves showed strong activity in improving glucose concentration in the oral glucose tolerance test. Our results showed that EtOAc fraction significantly decreased levels of glucose, total cholesterol (TC), low-density lipoprotein (LDL), and triglyceride (TG) and increased the level of high-density lipoprotein (HDL), and protected kidneys against damage in mice. EtOAc fraction also increased the levels of antioxidant enzymes, including catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD), and decreased malondial-dehyde (MDA) formation and pro-inflammatory cytokines (IL-1β and TNF-α) in kidney tissues. Moreover, the renoprotective effect was also observed in the histopathological analysis. Conclusion: Our findings support the fact that the EtOAc fraction of M. pudica leaves has potent anti-diabetic nephropathy activity by decreasing pro-inflammatory cytokines and improving antiox-idant levels. © 2022 Bentham Science Publishers.

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