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Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line
Journal of Natural Products Số 8, năm 2016 (Tập 79, trang 2053-2059)
DOI: 10.1021/acs.jnatprod.6b00381
Tài liệu thuộc danh mục: ISI, Scopus
J. Nat. Prod.
English
Từ khóa: 23 hydroxymangiferolic acid; 23 hydroxymangiferonic acid; 24 methylencycloartan 3,26 diol; 27 hydroxymangiferolic acid; 27 hydroxymangiferonic acid; ambolic acid; ambonic acid; ethinylestradiol; foliamangiferoside A; foliamangiferoside A1; isoambolic acid; mahkoside A; Mangifera indica extract; mangiferin; mangiferolate A; mangiferolate B; mangiferolic acid; mangiferonic acid; methylambolate; methylambonate; unclassified drug; antineoplastic agent; mangiferolate A; mangiferolate B; triterpene; Article; bark; carbon nuclear magnetic resonance; cell survival; chemical composition; controlled study; cytotoxicity; drug activity; drug isolation; drug structure; human; human cell; mango; nuclear magnetic resonance spectroscopy; pancreatic cancer cell line; proton nuclear magnetic resonance; chemical structure; chemistry; drug screening; isolation and purification; Mangifera; nuclear magnetic resonance; Pancreatic Neoplasms; Viet Nam; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Humans; Mangifera; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pancreatic Neoplasms; Plant Bark; Triterpenes; Vietnam
Tóm tắt tiếng anh
s that inhibit their viability during nutrition starvation represents a novel antiausterity strategy in anticancer drug discovery. A methanol extract of the bark of Mangifera indica was found to inhibit the survival of PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions with a PC50 value of 15.5 μg/mL, without apparent toxicity, in normal nutrient-rich conditions. Chemical investigation on this bioactive extract led to the isolation of 19 compounds (1-19), including two new cycloartane-type triterpenes, mangiferolate A (1) and mangiferolate B (2). The structures of 1 and 2 were determined by NMR spectroscopic analysis. Among the isolated compounds, mangiferolate B (2) and isoambolic acid (12) exhibited potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under the nutrition-deprived condition with PC50 values of 11.0 and 4.8 μM, respectively. © 2016 The American Chemical Society and American Society of Pharmacognosy.
