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Flavanonol glycosides from the stems of myrsine seguinii and their neuroprotective activities
Pharmaceuticals Số 9, năm 2021 (Tập 14, trang -)
ISSN: 14248247
ISSN: 14248247
DOI: 10.3390/ph14090911
Tài liệu thuộc danh mục:
Article
English
Từ khóa: 3'' o feruloylastilbin; 4'' o (3''',4''' dihydroxybenzoyl)astilbin; 4'' o (4''' hydroxybenzoyl)astilbin; 4'' o galloylastilbin; 4'' o galloylisoastilbin; 4'' o vanilloylastilbin; 4'' o vanilloylisoastilbin; astilbin; engeletin; isoastilbin; isoengeletin; neoastilbin; neuroprotective agent; unclassified drug; animal cell; Article; carbon nuclear magnetic resonance; circular dichroism; controlled study; cytotoxicity; DNA sequencing; drug determination; drug effect; electrospray mass spectrometry; HT22 cell line; medicinal plant; mouse; Myrsine seguinii; neuroprotection; nonhuman; nuclear magnetic resonance; physical chemistry; plant stem; proton nuclear magnetic resonance; ultra performance liquid chromatography; xylem
Tóm tắt tiếng anh
The accumulation of amyloid beta (Aβ) peptides is common in the brains of patients with Alzheimer’s disease, who are characterized by neurological cognitive impairment. In the search for materials with inhibitory activity against the accumulation of the Aβ peptide, seven undescribed flavanonol glycosides (1–7) and five known compounds (8–12) were isolated from stems of Myrsine seguinii by HPLC-qTOF MS/MS-based molecular networking. Interestingly, this plant has been used as a folk medicine for the treatment of various inflammatory conditions. The chemical structures of the isolated compounds (1–12) were elucidated based on spectroscopic data, including 1D and 2D nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS) and electronic circular dichroism (ECD) data. Compounds 2, 6 and 7 showed neuroprotective activity against Aβ-induced cytotoxicity in Aβ42-transfected HT22 cells. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
