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α-Glucosidase inhibition properties of cucurbitane-type triterpene glycosides from the fruits of Momordica charantia
Chemical and Pharmaceutical Bulletin Số 5, năm 2010 (Tập 58, trang 720-724)
ISSN: 92363
ISSN: 92363
DOI: 10.1248/cpb.58.720
Tài liệu thuộc danh mục: Scopus
Article
English
Từ khóa: aglycone; alpha glucosidase inhibitor; antidiabetic agent; charantoside A; charantoside B; charantoside C; glycoside; methanol; Momordica charantia extract; triterpene; unclassified drug; article; carbon nuclear magnetic resonance; cucumber; diabetes mellitus; drug isolation; drug structure; drug synthesis; enzyme inhibition; heteronuclear multiple bond correlation; heteronuclear multiple quantum coherence; Momordica charantia; nonhuman; proton nuclear magnetic resonance; alpha-Glucosidases; Animals; Enzyme Inhibitors; Fruit; Glycosides; Intestines; Molecular Structure; Momordica charantia; Rats; Triterpenes
Tóm tắt tiếng anh
Fourteen cucurbitane-type triterpene glycosides (1-14) were isolated from a methanol extract of Momordica charantia fruits, including three new compounds, charantosides A-C (1, 5, 6). Their structures were elucidated by chemical and spectroscopic methods. All isolated compounds were evaluated for α-glucosidase inhibitory effect. Of which, 12 and 13 showed moderate inhibitory activity against α-glucosidase. Whereas, 2, 3, 6-11, and 14 showed weak inhibitory activity, and 1, 4, and 5 were inactive. © 2010 Pharmaceutical Society of Japan.