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Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018

Yang , Chinese Academy of Sciences, Shanghai, China|
Hongjie (57218148331) | Simon (11940936200); Yu | Benjamin J. (8644765500); Cauchemez | Gabriel M. (7007159841); Cowling | Peter (7102203090); Leung | Peter W. (34975069600); Simmonds | H. Rogier (56941604800); Horby | Peng (7403119301); van Doorn | Weijia (36103493700); Wu | Shixiong (55475561200); Xing | Birgit (54417768800); Hu | Lidong (7401801034); Nikolay | Li (56865088700); Gao | Juliette (55159722600); Luo | Hongan (57980943100); Paireau | Ralf (55912813500); Hu | Qi (57205059761); Altmeyer | Bingbing (57204639293); Qiu | Jiaxin (57214595329); Dai | Xianglin (57219780406); Zhou Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom| Shuanbao (56822571900); Wei Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom| Wei (55543639500); Yu Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam| Gang (57982095600); Huang WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong| Yonghong (57203930159); Zou School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai’an, China| Fengfeng (55767119700); Zhou Infectious Diseases Department, Santé publique France, Saint-Maurice, France| Kaiwei (56229478500); Liu Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Université Paris Cité, UMR2000, CNRS, Paris, 75015, France| Qiaohong (23991218700); Luo Medusa Therapeutics Limited, Hong Kong| Juan (57234993700); Liao Anhua County Center for Disease Control and Prevention, Yiyang, China|

Nature Communications Số 1, năm 2022 (Tập 13, trang -)

ISSN: 20411723

ISSN: 20411723

DOI: 10.1038/s41467-022-34992-1

Tài liệu thuộc danh mục:

Article

English

Từ khóa: Antigens, Viral; Child; Child, Preschool; China; Enterovirus; Enterovirus A, Human; Enterovirus Infections; Hand, Foot and Mouth Disease; Humans; Infant, Newborn; Prospective Studies; Seroepidemiologic Studies; China; Pacific Ocean; Pacific Rim; maternal antibody; neutralizing antibody; virus vaccine; virus antigen; antibody; child health; cohort analysis; epidemiology; vaccination; vaccine; virus; antibody titer; Article; cesarean section; child; China; cohort analysis; congenital heart disease; controlled study; Enterovirus A71; Enterovirus infection; esophagus atresia; female; follow up; hand foot and mouth disease; human; incidence; longitudinal study; major clinical study; male; natural childbirth; nonhuman; population research; premature labor; preschool child; prospective study; school child; seroepidemiology; seroprevalence; term birth; time series analysis; vaccination; Enterovirus; Enterovirus A; Enterovirus infection; hand foot and mouth disease; newborn; seroepidemiology
Tóm tắt tiếng anh
Enterovirus A71 (EV-A71)–related hand, foot, and mouth disease (HFMD) imposes a substantial clinical burden in the Asia Pacific region. To inform policy on the introduction of the EV-A71 vaccine into the National Immunization Programme, we investigated the seroepidemiological characteristics of EV-A71 in two prospective cohorts of children in southern China conducted between 2013 and 2018. Our results show that maternal antibody titres declined rapidly in neonates, with over half becoming susceptible to EV-A71 at 1 month of age. Between 6 months and 2 years of age, over 80% of study participants were susceptible, while one third remained susceptible at 5 years old. The highest incidence of EV-A71 infections was observed in children aged 5-6 months. Our findings support EV-A71 vaccination before 6 months for birth cohorts in southern China, potentially with a one-time catch-up vaccination for children 6 months-5 years old. More regionally representative longitudinal seroepidemiological studies are needed to further validate these findings. © 2022, The Author(s).

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