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Tumor burden assessed by the maximum standardized uptake value and greatest diameter on FDG-PET predicts prognosis in untreated diffuse large B-cell lymphoma

Nguyen X.C. Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 166 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, South Korea|
Kim S.E. | Lee J.S. | Bang S.-M. Department of Nuclear Medicine Diagnosis and Therapy, Cairo University, Cairo, Egypt| Eo J.S. Department of Nuclear Medicine, Cho Ray Hospital, Ho Chi Minh City, Viet Nam| Amin A.M. Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, South Korea| Lee W.W. Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, South Korea|

Nuclear Medicine and Molecular Imaging Số 1, năm 2010 (Tập 44, trang 39-44)

ISSN: 18693474

ISSN: 18693474

DOI: 10.1007/s13139-009-0009-0

Tài liệu thuộc danh mục: Scopus

Article

English

Từ khóa: fluorodeoxyglucose f 18; Ki 67 antigen; adult; aged; article; cancer growth; cancer mortality; cancer staging; clinical article; diagnostic value; female; follow up; human; image analysis; International Prognostic Index; large cell lymphoma; male; overall survival; patient selection; positron emission tomography; priority journal; prognosis; progression free survival; questionnaire; sex difference; tumor volume
Tóm tắt tiếng anh
Purpose: It is uncertain whether the tumor burden as assessed using FDG-PET has prognostic significance in newly diagnosed diffuse large B-cell lymphoma (DLBCL). The authors undertook this study to determine whether a parameter that reflects both FDG uptake magnitude and the greatest tumor diameter is a prognostic indicator in DLBCL. Materials and Methods: Forty-two DLBCL patients (age, 57.4�15.5 years; male/female=25/17; stage I/II/III/IV=5/ 17/10/10) who underwent FDG-PET before chemotherapy were enrolled. A lesion with the highest maximum standardized uptake value (MaxSUV) on the PET image was selected, and size-incorporated MaxSUV (SIMaxSUV) of mass was calculated as MaxSUV � greatest diameter (mm) on the transaxial PET image. Median follow-up duration was 20.0 months. Results: Twelve (28.6%=12/42) patients experienced disease progression, and 10 (23.8%=10/42) died during follow-up. Among six variables [Ann Arbor stage, %Ki-67 expression, International Prognostic Index (IPI), MaxSUV, greatest diameter, and SIMaxSUV] investigated, only SIMaxSUV was found to be a single determinant of progression-free and overall survivals by multivariate analyses (p<0.05). Conclusion: These results suggest that SIMaxSUV, a new FDG-PET parameter that incorporates FDG uptake magnitude and the greatest tumor diameter, may be a useful indicator of prognosis in untreated DLBCL. � Korean Society of Nuclear Medicine 2010.

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