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Two new asterosaponins, archasterosides A and B, from the Vietnamese starfish Archaster typicus and their anticancer properties
Bioorganic and Medicinal Chemistry Letters Số 12, năm 2010 (Tập 20, trang 3826-3830)
ISSN: 0960894X
ISSN: 0960894X
DOI: 10.1016/j.bmcl.2010.04.005
Tài liệu thuộc danh mục: Scopus
Article
English
Từ khóa: aglycone; antineoplastic agent; archasteroside a; archasteroside b; immunoglobulin enhancer binding protein; oligosaccharide; protein p53; regularoside a; saponin derivative; transcription factor AP 1; unclassified drug; animal cell; antineoplastic activity; article; carbon nuclear magnetic resonance; controlled study; drug cytotoxicity; drug isolation; drug structure; HeLa cell; heteronuclear multiple bond correlation; human; human cell; mouse; nonhuman; proton nuclear magnetic resonance; starfish; transcription initiation; Animals; Antineoplastic Agents; Cell Line, Tumor; Hela Cells; Humans; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; NF-kappa B; Saponins; Starfish; Transcription Factor AP-1; Transcriptional Activation; Tumor Suppressor Protein p53; Archaster typicus; Asteroidea
Tóm tắt tiếng anh
New asterosaponins archasterosides A (1), B (2), and the known regularoside A (3) were isolated from the Vietnamese starfish Archaster typicus and structurally elucidated by extensive NMR techniques and chemical transformations. Compounds 1-3 showed moderate cytotoxic activities against HeLa and mouse JB6 P+ Cl41 cell lines. The most active, 2, induced basal AP-1- and p53-, but not NF-κB-transcriptional activations in JB6 Cl41 cells. © 2010 Elsevier Ltd.
