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Two nonrecombining sympatric forms of the human malaria parasite plasmodium ovale occur globally

Sutherland C.J. Health Protection Agency, Malaria Reference Laboratory, London, United Kingdom|
Polley S.D. | Imwong M. | Chiodini P.L. | Lockhart P.J. | Snounou G. | Day N.P.J. | White N.J. | Williams J. | Pain A. | Barnwell J.W. Alan Wilson Centre, Massey University, Palmerston North, New Zealand| Otto T.D. Department of Microbiology, National University of Singapore, Singapore, Singapore| Burke M. Westmead Hospital, Sydney, Australia| Nosten F. Centers for Disease Control and Prevention, Atlanta, GA, United States| Escalante A.A. School of Life Sciences, Arizona State University, Tempe, AZ, United States| Michon P. Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea| Arez A.P. Oxford University, Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam| Hien T.T. Royal Institute, Bangkok, Thailand| Dolecek C. Mahidol-Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand| Pukrittayakamee S. Department of Clinical Tropical Medicine, Mahidol University, Bangkok, Thailand| Jennison C. Sanger Genome Centre, Hinxton, United Kingdom| Oguike M. Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom| Nolder D. Hospital for Tropical Diseases, London, United Kingdom| Tanomsing N. Immunology Unit, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, United Kingdom|

Journal of Infectious Diseases Số 10, năm 2010 (Tập 201, trang 1544-1550)

ISSN: 221899

ISSN: 221899

DOI: 10.1086/652240

Tài liệu thuộc danh mục: Scopus

Article

English

Từ khóa: Africa; article; Asia; cell lineage; controlled study; gene amplification; gene locus; gene segregation; gene sequence; genetic analysis; genetic trait; hominid; leaf dimorphism; malaria; multilocus sequence typing; Myanmar; Nigeria; nonhuman; nucleotide sequence; parasite isolation; phylogeny; Plasmodium ovale; priority journal; Sao Tome and Principe; sequence analysis; Sierra Leone; species identification; sympatry; Uganda; United Kingdom; animal; classification; genetic variability; genetics; genotype; health; human; malaria; parasitology; ribosome RNA; Animals; Genetic Variation; Genotype; Humans; Malaria; Phylogeny; Plasmodium ovale; RNA, Ribosomal; World Health
Tóm tắt tiếng anh
Background. Malaria in humans is caused by apicomplexan parasites belonging to 5 species of the genus Plasmodium. Infections with Plasmodium ovale are widely distributed but rarely investigated, and the resulting burden of disease is not known. Dimorphism in defined genes has led to P ovale parasites being divided into classic and variant types. We hypothesized that these dimorphs represent distinct parasite species. Methods. Multilocus sequence analysis of 6 genetic characters was carried out among 55 isolates from 12 African and 3 Asia-Pacific countries. Results. Each genetic character displayed complete dimorphism and segregated perfectly between the 2 types. Both types were identified in samples from Ghana, Nigeria, S�o Tom�, Sierra Leone, and Uganda and have been described previously in Myanmar. Splitting of the 2 lineages is estimated to have occurred between 1.0 and 3.5 million years ago in hominid hosts. Conclusions. We propose that P ovale comprises 2 nonrecombining species that are sympatric in Africa and Asia. We speculate on possible scenarios that could have led to this speciation. Furthermore, the relatively high frequency of imported cases of symptomatic P ovale infection in the United Kingdom suggests that the morbidity caused by ovale malaria has been underestimated. � 2010 by the Infectious Diseases Society of America. All rights reserved.

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