LIÊN KẾT WEBSITE
Understand the role of natural killer
American Journal of Immunology Số 4, năm 2010 (Tập 6, trang 54-61)
ISSN: 1553619X
ISSN: 1553619X
DOI: 10.3844/ajisp.2010.54.61
Tài liệu thuộc danh mục: Scopus
Article
English
Từ khóa: caspase activated deoxyribonuclease; Fas ligand; gamma interferon; immunological adjuvant; interleukin 12; interleukin 2; methanol; osteoclast differentiation factor; plant extract; recombinant interleukin 2; Rhaphidophora korthalsii extract; tumor necrosis factor; tumor necrosis factor alpha; tumor necrosis factor related apoptosis inducing ligand; tumor vaccine; unclassified drug; acute granulocytic leukemia; anorexia; antibody dependent cellular cytotoxicity; antimicrobial activity; antineoplastic activity; article; cell activation; cell activity; cell count; cell expansion; cell granule; cell killing; cell therapy; cellular immunity; clinical trial; cutaneous T cell lymphoma; cytokine production; cytokine release; cytolysis; cytotoxic T lymphocyte; cytotoxicity; fever; human; hypotension; immune deficiency; immune system; immunocompetent cell; immunological memory; immunosuppressive treatment; immunotherapy; innate immunity; kidney carcinoma; leukocyte migration; lymphatic leukemia; lymphokine activated killer cell; melanoma; natural killer cell; natural killer cell base therapy; nonhuman; peripheral blood mononuclear cell; protein binding; tumor immunity; virus infection
Tóm tắt tiếng anh
Problem statement: Immunosuppression is a common approach for pathogens or cancer to escape from immune system of the infected host. Some of the antimicrobe or anticancer drugs may also weaken the body immune system. Among various types of immune cell, natural killer cells are the key component of the innate immunity which plays an important role in first line defense against cancer and microbe infections. Thus, understand the role of Natural killer cell can help to design a successful natural killer cell base therapy in cancer and infectious disease therapy. Approach: Natural killer cell unik activation/inhibition ligand, cytolytic granules and proinflammatory cytokiens offered a specific killing mechanism toward cancer or infected cell target. These specific activation can be achieved in the present of immunomodulator such as cytokines (IL-2 and IL-12) or mitogens (plant extract such as Rhaphidophora korthalsii methanol extract). Results: Key rule of Natural killer cell base immunotherapy is to maintain enough activated Natural killer cell number in the infected host. Conclusion/Recommendations: Future study should expand the clinical use of in vivo or ex-vivo Natural killer cell base therapy especially in cancer treatment. � 2010 Science Publications.
