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A new 26-norlanostane from Phlogacanthus turgidus growing in Vietnam
Journal of Asian Natural Products Research Số 2, năm 2022 (Tập 24, trang 196-202)
ISSN: 10286020
ISSN: 10286020
DOI:
Tài liệu thuộc danh mục:
Article
English
Từ khóa: Acanthaceae; alpha-Glucosidases; Cell Line, Tumor; Molecular Structure; Triterpenes; Vietnam; alpha glucosidase; betulic acid; betulin; cytotoxic agent; lupenone; lupeol; taxarexol; triterpenoid; turgidol; unclassified drug; alpha glucosidase; triterpene; Acanthaceae; Article; controlled study; cytotoxicity; density functional theory; drug isolation; drug structure; enzyme inhibition; human; IC50; K-562 cell line; mass spectrometry; nuclear magnetic resonance spectroscopy; Phlogacanthus turgidus; proton nuclear magnetic resonance; stereochemistry; Viet Nam; chemical structure; tumor cell line; Viet Nam
Tóm tắt tiếng anh
Chemical investigation on chloroform extract of Phlogacanthus turgidus led to the isolation of one new compound namely turgidol, together with five known triterpenoids, lupeol, lupenone, betulin, betulinic acid, and taraxerol. Their structures and stereochemistry have been determined by 1 D and 2 D NMR analysis, high resolution mass spectrometry, and compared with those in literatures. The relative configuration of turgidol was defined using DFT-NMR chemical shift calculations and subsequent DP4+ probability method. Turgidol, betulin, and betulinic acid were evaluated for cytotoxic activity toward K562 cancer cell line and the alpha-glucosidase inhibition. � 2021 Informa UK Limited, trading as Taylor & Francis Group.
