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Aplydactylonins A-C, three new sesquiterpenes from the Vietnamese sea hare Aplysia dactylomela and their cytotoxicity
Journal of Natural Medicines Số 1, năm 2022 (Tập 76, trang 210-219)
ISSN: 13403443
ISSN: 13403443
DOI:
Tài liệu thuộc danh mục:
Article
English
Từ khóa: aplydactylonin A; aplydactylonin B; aplydactylonin C; camptothecin; caspase 3; sesquiterpene; unclassified drug; A-549 cell line; antineoplastic activity; Aplysia dactylomela; apoptosis; Article; cancer inhibition; controlled study; drug conformation; drug cytotoxicity; drug isolation; drug sensitivity; drug structure; DU145 cell line; enzyme activity; G1 phase cell cycle checkpoint; Hep-G2 cell line; human; human cell; IC50; in vitro study; liver cell carcinoma; lung carcinoma; proapoptotic activity; prostate carcinoma
Tóm tắt tiếng anh
Aplydactylonins A-C (1–3), three new sesquiterpenes, were isolated from the Vietnamese sea hare Aplysia dactylomela. Their structures and absolute configurations were elucidated based on spectroscopic analysis, X-ray crystallography, and density functional theory (DFT) calculations of NMR and ECD data. Compound 2 exhibited cytotoxicity against HepG2, DU145 and A549 cells with respective IC50 values of 4.08 ± 0.63, 38.64 ± 1.04 and 12.33 ± 0.95 µM. In addition, HepG2 cells treated with 5 μM compound 2 for 48 h showed a significant increase in early apoptotic cells (P < 0.05) and increased caspase 3 activity (P < 0.01). Moreover, compound 2 induced sub-G1 phase arrest in HepG2 cells. © 2021, The Japanese Society of Pharmacognosy.
