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Control of Obesity, Blood Glucose, and Blood Lipid with Olax imbricata Roxb. Root Extract in High-Fat Diet-Induced Obese Mice
Journal of Toxicology Số , năm 2022 (Tập 2022, trang -)
ISSN: 16878191
ISSN: 16878191
DOI:
Tài liệu thuộc danh mục:
Article
English
Từ khóa: acarbose; alpha glucosidase; antidiabetic agent; antilipemic agent; antiobesity agent; cholesterol; fat droplet; glucose; hexane; high density lipoprotein; insulin; lipid; low density lipoprotein; olax imbricata root extract; plant extract; triacylglycerol; unclassified drug; adipocyte; adipose tissue weight; animal experiment; animal model; animal tissue; Article; body weight gain; caloric intake; controlled study; diet-induced obesity; drug megadose; enzyme inhibition; glucose blood level; glucose tolerance; histopathology; hyperlipidemia; immigration; impaired glucose tolerance; in vitro study; in vivo study; insulin deficiency; kidney proximal tubule; kidney tissue; lipid blood level; lipid storage; liver tissue; locomotion; male; mouse; nonhuman; obesity management; Olacaceae; Olax imbricata; total cholesterol level; travel; triacylglycerol blood level; white adipose tissue
Tóm tắt tiếng anh
Mice were used in in vivo experiments to evaluate the effects of doses of n-hexane extract (from 100 to 1,300 mg/kg body weight/day) on the ability to control obesity, blood glucose, and blood lipid. In this study, body weight gain, caloric intake, glucose tolerance, blood lipid, histopathological study, and locomotion activity were examined. Furthermore, this study evaluated the lethality of the extract in extremely high doses in the tested mice. After 3 months of use with an extremely high dose of 5,000 mg/kg body weight/day (equivalent to 350 g/day for a 70 kg person), no animals with abnormal conditions or death were observed. This initially demonstrated the safety of the extract. In addition, after 6 weeks of testing on high-fat diet-induced obese mice, n-hexane extract at a dose of 500 mg/kg body weight/day (equivalent to 35 g/day for a 70 kg person) demonstrated a positive effect on the ability to control obesity, blood glucose, and blood lipid through the results of body weight, blood lipids, glucose tolerance, and histopathology (white fat, liver, and kidney tissues). In this study, n-hexane extract from the roots of Duong-dau tree has proven to be strongly biologically active in preventing and supporting the treatment of diseases related to overweight and obesity, helping to control blood glucose levels thereby reducing the risk of type 2 diabetes. � 2022 Thi Nga Vo et al.
