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Crinane, augustamine, and β-carboline alkaloids from Crinum latifolium

Hanh T.T.H. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam|
Minh C.V. | Nam N.H. | Cuong N.X. | Cuong N.T. | Mai N.T. | Cuong T.V. Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam| Trung N.Q. Institute of Ecology and Biological Resources, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam| Thanh N.V. University of Transport and Communications, 3 Cau Giay, Dong Da, Hanoi, Viet Nam| Huong P.T.T. Center for High Technology Development, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam| Anh D.H. Center for Research and Technology Transfer, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam|

Phytochemistry Letters Số , năm 2018 (Tập 24, trang 27-30)

DOI: 10.1016/j.phytol.2018.01.004

Tài liệu thuộc danh mục: Scopus

Phytochem. Lett.

English

Từ khóa: 6 hydroxybuphanidrine; 6 methoxycrinamidine; 6 methoxyundulatine; alkaloid derivative; ambelline; antineoplastic agent; augustamine; crinamidine; Crinum latifolium extract; filifoline; perlolyrine; plant extract; unclassified drug; undulatine; undulatine n oxide; antineoplastic activity; Article; carbon nuclear magnetic resonance; controlled study; Crinum; Crinum latifolium; drug cytotoxicity; Hep-G2 cell line; heteronuclear multiple bond correlation; human; human cell; IC50; LNCaP cell line; MCF-7 cell line; nuclear Overhauser effect; plant leaf; priority journal
Tóm tắt tiếng anh
Three new crinane-type alkaloids, namely, 6-methoxyundulatine (1), 6-methoxycrinamidine (2), and undulatine N-oxide (3), along with the known compounds 6-hydroxyundulatine (4), 6-hydroxybuphanidrine (5), undulatine (6), crinamidine (7), ambelline (8), filifoline (9), augustamine (10), and perlolyrine (11), were isolated from the leaves of Crinum latifolium by using various chromatographic separations. Their structures were established by extensive analysis, including 1D and 2D NMR, HR-QTOF-MS, and CD data. Among the isolated compounds, perlolyrine (11) showed significant cytotoxicity against five human cancer cell lines, namely, KB, HepG2, MCF7, SK-Mel2, and LNCaP with the IC50 values ranging from 22.12 ± 2.80 to 28.45 ± 3.75 μM. © 2018 Phytochemical Society of Europe

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