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Effect of mixed Camellia chrysantha, Gynostemma pentaphyllum and Celastrus hindsii Extract on Atherosclerotic Rat Models
Tropical Journal of Natural Product Research Số 3, năm 2022 (Tập 6, trang 354-360)
ISSN: 26160684
ISSN: 26160684
DOI:
Tài liệu thuộc danh mục:
Article
English
Từ khóa: antilipemic agent; atorvastatin; Camellia chrysantha extract; Celastrus hindsii extract; cholesterol; Gynostemma pentaphyllum extract; high density lipoprotein; low density lipoprotein; plant extract; triacylglycerol; unclassified drug; abdominal aorta; animal experiment; animal model; animal tissue; Article; atherogenic index; atheroma; atherosclerosis; atherosclerotic plaque; blood sampling; Camellia; cardiovascular disease; Celastrus; combination drug therapy; controlled study; drug mixture; dyslipidemia; foam cell; Gynostemma pentaphyllum; herb; histopathology; in vivo study; incidence; lipid diet; lipid peroxidation; liver; nonalcoholic fatty liver; nonhuman; oxidative stress; plant stem; prevalence; rat; rat model; risk factor; Wistar rat
Tóm tắt tiếng anh
Atherosclerotic disease occurs due to lifestyle choices, such as being sedentary, eating fast foods, and a lack of physical exercise. Atherosclerosis has gradually become the leading cause of death worldwide. Currently, the trend of using natural herbal products to supplement and replace synthetic drugs is being considered in Vietnam. This study aims to evaluate the in vivo anti-atherosclerotic effect of a mixture extract of C. chrysantha, G. pentaphyllum, and C. hindsii in a Wistar rat model. Wistar rats were randomly assigned to 5 groups with 10 animals in each group and blood samples were obtained from rats at 0, 14, and 28 days after treatment began to examine blood lipid indicators: triglyceride (TG), total cholesterol (TC), high-density lipoproteins (HDL-C), and low-density lipoproteins (LDL-C). The results showed that a mixture of C. chrysantha, G. pentaphyllum, and C. hindsii extracts at doses of 16.8 and 33.6 g/kg/day reduced blood lipid test indexes, including triglyceride levels, total cholesterol, LDL-cholesterol, and atherogenic index. At the same time, this mixture increased the levels of HDL-cholesterol in the blood, reduced the incidence of fatty liver, and protected against atherosclerotic lesions of the abdominal aorta in the studied rats. These initial findings contribute to the search for new sources of raw materials and the development of natural products to prevent and treat atherosclerosis. � 2022 Nguyen et al.
