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New meta-depsidones and diphenyl ethers from the lichen Parmotrema tsavoense (Krog & Swinscow) Krog & Swinscow, Parmeliaceae
Tetrahedron Số 52, năm 2015 (Tập 71, trang 9684-9691)
ISSN: 404020
ISSN: 404020
DOI: 10.1016/j.tet.2015.06.107
Tài liệu thuộc danh mục: ISI, Scopus
Article
English
Từ khóa: 2 o methylatranol; 8' o methylprotocetraric acid; acetic acid ethyl ester; antineoplastic agent; atranorin; camptothecin; diphenyl ether derivative; methyl beta orsellinate; methyl haematommate; methyl orsellinate; parmoether a; parmoether b; parmosidone a; parmosidone b; parmosidone c; parmosidone d; parmosidone e; prasorediosic acid; protocetraric acid; unclassified drug; virensic acid; zeorin; Article; breast cancer cell line; carbon nuclear magnetic resonance; chemical structure; concentration response; controlled study; drug cytotoxicity; drug isolation; drug synthesis; HepG2 cell line; human; human cell; lung cancer cell line; mass spectrometry; medicinal plant; Parmotrema tsavoense; priority journal; proton nuclear magnetic resonance; structure activity relation
Tóm tắt tiếng anh
Chemical investigation of the ethyl acetate extract of lichen Parmotrema tsavoense (Krog & Swinscow) Krog & Swinscow, Parmeliaceae, collected in Vietnam, afforded 7 new secondary metabolites, including 5 new meta-depsidones (1-5), 2 new diphenyl ethers (6, 7), together with 10 known compounds. Their chemical structures were elucidated by analysis of 1D and 2D NMR and high-resolution mass spectroscopic data, as well as by comparison with those reported in the literature. We also proposed a possible biosynthetic route for the formation of new compounds of P. tsavoense from the readily accessible precursors atranorin and methyl β-orsellinate. The cytotoxic activities of five new compounds against liver hepatocellular carcinoma (HepG2), human lung cancer (NCI-H460) and human breast cancer (MCF-7) cell lines were evaluated. © 2015 Elsevier Ltd.
