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Phenolic constituents from the leaves of Cratoxylum formosum ssp. pruniflorum
Fitoterapia Số , năm 2014 (Tập 94, trang 114-119)
ISSN: 0367326X
ISSN: 0367326X
DOI: 10.1016/j.fitote.2014.02.002
Tài liệu thuộc danh mục: Scopus
Article
English
Từ khóa: 11 hydroxy 5 methoxy 2,2,9 trimethyl 2h anthra [1,2 b] pyran 7,12 dione; 2' hydroxy 4',4' dimethyl pyran 1,5 dihydroxyxanthone; 2' hydroxymethyl 3',3' dimethyl dihydrofuran 1,5 dihydroxyxanthone; 2,3 trans dihydro kaemferol; 5,7 dihydroxychromone; amyloid beta protein[25-35]; flavanone; formosumone a; formoxanthone c; gb 1; gb 1a; gb 2; gb 2a; lipopolysaccharide; neuroprotective agent; nitric oxide; phenol derivative; phloroglucinol; physcion; toxyloxanthone b; unclassified drug; vismiaquinone; vismione b; vismione d; 11 hydroxy 5 methoxy 2,2,9 trimethyl 2h anthra[1,2 b]pyran 7,12 dione; 2' hydroxy 4',4' dimethylpyran 1,5 dihydroxyxanthone; 2' hydroxymethyl 3',3' dimethyldihydrofuran 1,5 dihydroxyxanthone; 2,3 dihydrokaemferol; amyloid beta protein[25-35]; antiinflammatory agent; Cratoxylum formosum pruniflorum extract; formosumone A; formoxanthone C; n(g) methylarginine; naringenin(3-8) 5,7 dihydroxychromone; nitric oxide; plant extract; pruniflorone M; pruniflorone N; toxyloxanthone B; vismione B; vismione D; anthraquinone derivative; antiinflammatory agent; flavonoid; neuroprotective agent; phenol derivative; plant extract; xanthone derivative; animal cell; animal experiment; antineuroinflammatory activity; article; carbon nuclear magnetic resonance; cell viability; Clusiaceae; comparative study; controlled study; Cratoxylum formosum ssp pruniflorumm; drug activity; drug isolation; drug structure; heteronuclear multiple bond correlation; IC 50; microglia; mouse; neuroblastoma cell; neuroprotection; nonhuman; nuclear Overhauser effect; physical chemistry; plant leaf; priority journal; Southeast Asia; tea; antiinflammatory activity; Article; biosynthesis; cell viability assay; Cratoxylum formosum pruniflorum; drug efficacy; human; human cell; medicinal plant; nervous system inflammation; structure analysis; animal; cell line; cell survival; chemical structure; chemistry; drug effects; isolation and purification; metabolism; nuclear magnetic resonance spectroscopy; plant leaf; Clusiaceae; Cratoxylum formosum; Murinae; Animals; Anthraquinones; Anti-Inflammatory Agents; Cell Line; Cell Survival; Clusiaceae; Flavonoids; Lipopolysaccharides; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Neuroprotective Agents; Nitric Oxide; Phenols; Plant Extracts; Plant Leaves; Xanthones
Tóm tắt tiếng anh
One (formosumone A, 1) new and fifteen (2-16) known phenolic compounds were isolated from the leaves of Cratoxylum formosum ssp. pruniflorumm, a substitute for the popular bitter nail tea ("Kuding Tea") generally used in Southeast Asia. Their structures were determined by extensive spectroscopic analysis and by comparison with literature data. Compound 1 possesses a rare scaffold of a flavanone coupled with a phloroglucinol moiety, representing the first example of such a scaffold from the Clusiaceae family. Among the isolates, toxyloxanthone B (11) and vismione D (12) were found to show remarkable anti-neuroinflammatory effects by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells. Additionally, toxyloxanthone B (11) exhibited significant neuroprotective effect against β-amyloid25-35 (Aβ25-35)-induced cell viability decrease in SH-SY5Y neuroblastoma cells. © 2014 Elsevier B.V.
