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The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria

Srinamon Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand|
Nicholas J. (7401767314) | Nicholas P. J. (57708938700); White | Arjen M. (35462577600); Day | Kesinee (55979038200); Dondorp | Lorenz (7003391764); Chotivanich | Caterina (6602452712); von Seidlein | Kirsten E. (6603189919); Fanello | Pham Thi (57213513214); Lyke | Nguyen Hoan (57682342000); Diep | Benjamas (56294458100); Phu Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States| Kamolrat (57208458283); Intharabut WorldWide Antimalarial Resistance Network, Oxford, United Kingdom| James A. (57202220570); Silamut Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, New Richards Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7LG, United Kingdom| Ketsanee (57208511761); Watson Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam|

Nature Communications Số 1, năm 2022 (Tập 13, trang -)

ISSN: 20411723

ISSN: 20411723

DOI: 10.1038/s41467-022-34678-8

Tài liệu thuộc danh mục:



Từ khóa: Child; Hemeproteins; Humans; Malaria; Malaria, Falciparum; Prognosis; Africa; artemether; artesunate; pigment; quinine; hemoprotein; hemozoin; blood; cause of death; disease severity; meta-analysis; parasite; pigment; spatiotemporal analysis; adult; African; Article; blood cell count; child; controlled study; diagnostic value; double blind procedure; hospital patient; human; in-hospital mortality; major clinical study; malaria falciparum; microscopy; monocyte; neutrophil; patient coding; prognosis; prognostic assessment; prospective study; randomized controlled trial; malaria; malaria falciparum; meta analysis; parasitology
Tóm tắt tiếng anh
Severe falciparum malaria is a major cause of death in tropical countries, particularly in African children. Rapid and accurate diagnosis and prognostic assessment are critical to clinical management. In 6027 prospectively studied patients diagnosed with severe malaria we assess the prognostic value of peripheral blood film counts of malaria pigment containing polymorphonuclear leukocytes (PMNs) and monocytes. We combine these results with previously published data and show, in an individual patient data meta-analysis (n = 32,035), that the proportion of pigment containing PMNs is predictive of in-hospital mortality. In African children the proportion of pigment containing PMNs helps distinguish severe malaria from other life-threatening febrile illnesses, and it adds to the prognostic assessment from simple bedside examination, and to the conventional malaria parasite count. Microscopy assessment of pigment containing PMNs is simple and rapid, and should be performed in all patients hospitalised with suspected severe malaria. � 2022, The Author(s).

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