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Two acridones and two coumarins from the roots of Paramignya trimera
Tetrahedron Letters Số 16, năm 2017 (Tập 58, trang 1553-1557)
DOI: 10.1016/j.tetlet.2017.02.083
Tài liệu thuộc danh mục: Scopus
Final
English
Từ khóa: 5 hydroxynoracronycin; acarbose; acridone derivative; alpha glucosidase; citrusinine I; coumarin derivative; daedalin A; glycocitrine III; herbaceous agent; ninhvanin; oriciacridone E; ostruthin; pandanusin A; Paramignya trimera extract; paratrimerin C; paratrimerin D; paratrimerin E; paratrimerin F; plant extract; scopoletin; umbelliferone; unclassified drug; vanillic acid; xanthyletin; Article; biosynthesis; carbon nuclear magnetic resonance; IC50; Paramignya trimera; plant root; proton nuclear magnetic resonance; Rutaceae
Tóm tắt tiếng anh
Two acridones, paratrimerins C (1) and D (2), and two coumarins, paratrimerins E (3) and F (4), were isolated from the CHCl3 and EtOAc extracts of Paramignya trimera (Rutaceae), together with twelve known compounds (5–16). Their structures were elucidated on the basis of spectroscopic data. All isolated compounds possessed significant α-glucosidase inhibitory activity in a concentration-dependent manner, and showed more potent inhibitory activity, with IC50 values ranging from 14.6 to 112.2 μM, than the positive control acarbose (IC50, 214.5 μM). The biosynthesis of the isolated coumarins and acridones was proposed. © 2017 Elsevier Ltd
